Toxicological study on DINP exposure
The toxicological study “Systematic Comparison of the Male Reproductive Tract in Fetal and Adult Wistar Rats exposed to DBP and DINP in utero during the Masculinisation Programming Window”, conducted at the University of Edinburgh, was just published by Van den Driesche et al. (2020) in the peer-reviewed Journal Toxicology Letters.
The study investigates possible effects of in utero exposure of rats to a low dose (125 mg/kg bw/day) and a high dose (750 mg/kg bw/day) of Diisononyl phthalate (DINP) and makes a comparison with (Dibutyl phthalate) DBP, used as a positive control.
Overall, the results of this systematic comparison provide convincing evidence on the differences between the effects occurring with DBP and the lack of effects by DINP. The results of the study demonstrate that DINP does not cause the adverse reproductive effects known to occur with DBP, identified as an endocrine disruptor under REACH due to the adverse reproductive effects being associated with a decrease in testosterone levels.
The study supports the robust weight of evidence opinion of RAC 2018 on DINP confirming that DINP does not show any adverse reproductive effects.
"The publication of the study undertaken at the University of Edinburgh demonstrates once again the engagement of European Plasticisers within the scientific community and our commitment to plasticisers", commented Rainer Otter, Chair of the Scientific Working Group.